세션명
|
Korea-Australia Joint Symposium: Functional Macromolecules for Advanced Applications (English) |
발표장
|
제8회장 |
논문코드
|
1L8-3 |
발표일
|
2021-10-21 |
발표시간
|
14:50-15:15 |
논문제목
|
Dendronised Polymers as a Delivery Platform |
발표자
|
Cameron W. Evans |
발표자 소속
|
The University of Western Australia |
저자
|
Cameron W. Evans† |
소속
|
The University of Western Australia |
논문초록
|
Dendronised polymers represent a highly uniform class of grafted macromolecules that are useful in a number of biological applications. The dendronised polymer architecture consists of a macromolecular backbone to which monodisperse, branched molecules (dendrons) are attached. We have prepared dendronised polymers with a high level of control, including the engineering of regular point defects within the dendron structure to investigate the effects of flexibility and charge distribution in the delivery of genetic cargo. I will discuss our work using these materials and describe their application to biological systems, including intracellular delivery of nucleic acids and proteins, single-cell sequencing, and as a highly tunable platform for preparing hydrogels. |